Mailing Address:
Division of Environmental Health Sciences
300 West 10th Avenue; Room 1148A
The Arthur G. James Cancer Hospital
and Richard J. Solove Research Institute
Columbus, OH 43210
Contact Info:
Phone: (614) 293-6063
Fax: (614) 292-6485
Send me an email
Education:
1984 B.A. Biology, Mount Vernon Nazarene University, Mount Vernon, Ohio
1989 Ph.D. Biomedical Sciences (Pathology), Medical College of Ohio, Toledo, Ohio
Appointments and memberships:
American Association for Cancer Research
Society of Toxicology
Molecular Events in Progression/Prevention of Oral Cancer”/Project 3 “Inactivation of the TGFß Receptor Complex in Oral Cancer Development
Prevention of Experimental Oral Cancer by Topical Application of Natural Food Products
Chemoprevention Screening in Mutant Mouse Models by Agents that Inhibit Inflammation
Chemopreventive Agent-Responsive Genes in Oral Cancer
Apoptotic Mechanisms of NSAID Chemoprevention
Courses Taught:
Principles of Environmental Health (PEP)
Molecular Techniques for EHS
Selected Publications:
Bian Y, Knobloch TJ, Sadim M, Kaklamani V, Raji A, Yang GY, Weghorst CM, Pasche B. Somatic acquisition of TGFBR1*6A by epithelial and stromal cells during head and neck and colon cancer development. Hum Mol Genet. 2007 Dec 15;16(24):3128-35. Epub 2007 Sep 21. PMID: 17890272 [PubMed - in process]
Mahajan A, Guo Y, Yuan C, Weghorst CM, Tsai MD, Li J. Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16. J Mol Biol. 2007 Nov 2;373(4):990-1005. Epub 2007 Aug 22. PMID: 17881001 [PubMed - in process]
Pasche B, Knobloch TJ, Bian Y, Liu J, Phukan S, Rosman D, Kaklamani V, Baddi L, Siddiqui FS, Frankel W, Prior TW, Schuller DE, Agrawal A, Lang J, Dolan ME, Vokes EE, Lane WS, Huang CC, Caldes T, Di Cristofano A, Hampel H, Nilsson I, von Heijne G, Fodde R, Murty VV, de la Chapelle A, Weghorst CM. Somatic acquisition and signaling of TGFBR1*6A in cancer. JAMA. 2005 Oct 5;294(13):1634-46. PMID: 16204663 [PubMed - indexed for MEDLINE]
Li J, Muscarella P, Joo SH, Knobloch TJ, Melvin WS, Weghorst CM, Tsai MD. Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A). Biochemistry. 2005 Oct 11;44(40):13246-56. PMID: 16201750 [PubMed - indexed for MEDLINE]
Li J, Weghorst CM, Tsutsumi M, Poi MJ, Knobloch TJ, Casto BC, Melvin WS, Tsai MD, Muscarella P. Frequent p16INK4A/CDKN2A alterations in chemically induced Syrian golden hamster
pancreatic tumors. Carcinogenesis. 2004 Feb;25(2):263-8. Epub 2003 Nov 6. PMID: 14604895 [PubMed - indexed for MEDLINE]
Li J, Qin D, Knobloch TJ, Tsai MD, Weghorst CM, Melvin WS, Muscarella P. Expression and characterization of Syrian golden hamster p16, a homologue of human tumor suppressor p16 INK4A. Biochem Biophys Res Commun. 2003 May 2;304(2):241-7. PMID: 12711305 [PubMed - indexed for MEDLINE]
Casto BC, Kresty LA, Kraly CL, Pearl DK, Knobloch TJ, Schut HA, Stoner GD, Mallery SR, Weghorst CM. Chemoprevention of oral cancer by black raspberries. Anticancer Res. 2002 Nov-Dec;22(6C):4005-15. PMID: 12553025 [PubMed - indexed for MEDLINE]
Kresty LA, Mallery SR, Knobloch TJ, Song H, Lloyd M, Casto BC, Weghorst CM. Alterations of p16(INK4a) and p14(ARF) in patients with severe oral epithelial dysplasia. Cancer Res. 2002 Sep 15;62(18):5295-300. PMID: 12234999 [PubMed - indexed for MEDLINE]
Lang JC, Borchers J, Danahey D, Smith S, Stover DG, Agrawal A, Malone JP, Schuller DE, Weghorst CM, Holinga AJ, Lingam K, Patel CR, Esham B. Mutational status of overexpressed p16 in head and neck cancer: evidence for germline mutation of p16/p14ARF. Int J Oncol. 2002 Aug;21(2):401-8. PMID: 12118338 [PubMed - indexed for MEDLINE]
Muscarella P, Knobloch TJ, Ulrich AB, Casto BC, Moniaux N, Wittel UA, Melvin WS, Pour PM, Song H, Gold B, Batra SK, Weghorst CM. Identification and sequencing of the Syrian Golden hamster (Mesocricetus auratus) p16(INK4a) and p15(INK4b) cDNAs and their homozygous gene deletion in cheek pouch and pancreatic tumor cells. Gene. 2001 Oct 31;278(1-2):235-43. PMID: 11707341 [PubMed - indexed for MEDLINE]
Seijo ER, Song H, Lynch MA, Jennings R, Qong X, Lazaridis E, Muro-Cacho C, Weghorst CM, Muñoz-Antonia T. Identification of genetic alterations in the TGFbeta type II receptor gene
promoter. Mutat Res. 2001 Nov 1;483(1-2):19-26. PMID: 11600128 [PubMed - indexed for MEDLINE]
Knobloch TJ, Lynch MA, Song H, DeGroff VL, Casto BC, Adams EM, Alam KY, Lang JC, Schuller DE, Weghorst CM. Analysis of TGF-beta type I receptor for mutations and polymorphisms in head and neck cancers. Mutat Res. 2001 Aug 8;479(1-2):131-9. PMID: 11470488 [PubMed - indexed for MEDLINE]
Lynch MA, Petrel TA, Song H, Knobloch TJ, Casto BC, Ramljak D, Anderson LM, DeGroff V, Stoner GD, Brueggemeier RW, Weghorst CM. Responsiveness to transforming growth factor-beta (TGF-beta)-mediated growth inhibition is a function of membrane-bound TGF-beta type II receptor in human breast cancer cells. Gene Expr. 2001;9(4-5):157-71. PMID: 11444526 [PubMed - indexed for MEDLINE]
Poi MJ, Yen T, Li J, Song H, Lang JC, Schuller DE, Pearl DK, Casto BC, Tsai MD, Weghorst CM. Somatic INK4a-ARF locus mutations: a significant mechanism of gene inactivation in squamous cell carcinomas of the head and neck. Mol Carcinog. 2001 Jan;30(1):26-36. PMID: 11255261 [PubMed - indexed for MEDLINE]
Shirin H, Sordillo EM, Kolevska TK, Hibshoosh H, Kawabata Y, Oh SH, Kuebler JF, Delohery T, Weghorst CM, Weinstein IB, Moss SF. Chronic Helicobacter pylori infection induces an apoptosis-resistant phenotype associated with decreased expression of p27(kip1). Infect Immun. 2000 Sep;68(9):5321-8. PMID: 10948161 [PubMed - indexed for MEDLINE]
